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Human-primate divergence is reduced at putatively neutral sites near selected sites.

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posted on 10.08.2016, 17:30 by Tanya N. Phung, Christian D. Huber, Kirk E. Lohmueller

(A) Neutral human-chimp divergence is negatively correlated with functional content. (B) Neutral human-orang divergence is negatively correlated with functional content. (C) Neutral human-chimp divergence is positively correlated with human recombination rate. (D) Neutral human-orang divergence is positively correlated with human recombination rate. Each point represents the mean divergence and functional content (A and B) or recombination rate (C and D) in 1% of the 100kb windows binned by functional content or recombination rate. Red lines indicate the loess curves fit to divergence and functional content (A and B) and divergence and recombination rate (C and D). The high variance of divergence at regions of low recombination rate is expected since the variance of divergence is inversely proportional to the recombination rate. Note that the last bin containing less than 1% of the windows was omitted from the plot. While the graph presents binned data, the correlations reported in the text are from the unbinned data.

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