Histopathology of PDGFA/p53 shRNA-driven brain tumors.
(A) Hematoxylin and eosin staining of whole brain slice with colored boxes highlighting areas of particular interest. (B) Red box = representative sample taken from the invasive edge of the tumor. Arrowheads indicate tumor invasion into adjacent brain tissue. (C) Blue box = hypercellular tumor with regions of pseudopallisading necrosis. (D) Yellow box = areas of microvascular proliferation, hypercellularity, and pleomorphism. (Scale bar = 200 μm).