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Histograms the number of intermolecular H-bonds vs the probability of occurrence in different systems between flavonoids-Aβ42.

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posted on 28.06.2018, 17:33 by Sahar Andarzi Gargari, Abolfazl Barzegar, Alireza Tarinejad

Subscripts refer to the corresponding flavonoids numbers.

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The role of phenolic OH groups of flavonoid compounds with H-bond formation ability to suppress amyloid mature fibrils by destabilizing β-sheet conformation of monomeric Aβ17-42
PLOS ONEPLOS ONE

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brain cellsfibrilH-bond formation abilitypeptideflavonoid compoundsaggregation6 OHsbinding factorSASA-dependent energystrandflavonemole ratio-dependent effectsMyricetinphenolic OH groupsmyricetinmorin polyphenols form H-bondsMDamyloidU-shape rod-like stateprotofilamentbinding energiesmonomeric U-shape5 OHsinteraction featuresAD patientsbrain diseasemole ratiospolyphenolic flavonoidsamine substitutioncomplexamine groups

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