High PSAT1 gene expression is correlated with enrichments in immune-related pathways.

E2F targets, interferon α and γ, complement system components, and mTORC1 hallmarks were identified as being enriched and showed a strong correlation with elevated PSAT1 expression levels. (A-E) Gene set enrichment analysis (GSEA) was performed on differentially expressed genes associated with PSAT1 gene expression (High vs. Low). This analysis resulted in a set of significant hallmark signatures associated with the immune system. Hallmarks with a false discovery rate (FDR) below 0.05 were considered significant. (F-J) Genes associated with each previous hallmark were assessed in terms of gene expression further to evaluate their contribution to the aforementioned significant hallmarks. Scatter plots showed, indeed, the upregulation of immune-related genes with MDS samples with high PSAT1 gene expression.