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Hematoxylin/eosin and immunohistochemical staining of tissues from CCHFV-challenged cynomolgus macaques and comparison to mouse controls.

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posted on 2020-08-13, 17:55 authored by Robert W. Cross, Abhishek N. Prasad, Viktoriya Borisevich, Joan B. Geisbert, Krystle N. Agans, Daniel J. Deer, Karla A. Fenton, Thomas W. Geisbert

Representative H&E-stained tissue specimens (A,C,E,G,I,K,M,O,Q,S) and IHC antibody labeled tissue specimens (B,D,F,H,J,L,N,P,R,T). For IHC images, CCHFV antigen labeling (NP protein), if present, is shown in brown. Panels A,B,E,F,I,J,M,N are from subject 1-A5-C2, challenged with the Afghanistan isolate, and are representative of what was observed in all subjects challenged with this isolate. Panels C,D,G,H,K,L,O,P are from subject 1-H10-C2, challenged with the Hoti isolate, and are representative of what was observed in all subjects challenged with this isolate. Panels Q and R are of the liver from a historical control mouse that succumbed to infection by the Afghanistan isolate. Panels S and T are of the liver from a historical control mouse that succumbed to infection by the Hoti isolate. All images were captured at 20X magnification.

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