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HOTAIR regulates COX-2 expression and PGE2 production in cervical cancer cells.

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posted on 13.10.2016, 17:57 by Lixin Zhang, Hua Qian, Min Sha, Zhengyun Luan, Mei Lin, Donglan Yuan, Xiaokang Li, Junxing Huang, Lihua Ye

After transfected with pcDNA3.1 or pcDNA3.1-HOTAIR for 24 h, CaSki and Hela cells were treated with ART (50 mmol/l) for 24 h. Then, (A) COX-2 mRNA level, (B) COX-2 protein level and (C) PGE2 concentration were measured. **P < 0.01, compared to pcDNA3.1. ##P < 0.01, compared to pcDNA3.1 + ART.