Generation and validation of a CCR2-Cre mouse.
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posted on 2019-03-21, 17:27 authored by Lena J. Heung, Tobias M. Hohl(A) Schematic of the modification of a BAC containing the endogenous CCR2 locus in order to insert the Cre recombinase gene, a stop codon, and a frameshift mutation downstream of the CCR2 promoter. (B) Representative flow plots and histograms of tdRFP expression by IM in the bone marrow, blood and lung of naive CCR2-Cre Rosa26flSTOP-tdRFP mice. The dotted lines in the histograms represent naive Rosa26flSTOP-tdRFP control mice.
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M 2 marker arginase 1CCR 2MHC class II expressioneosinophil recruitmentCryptococcus neoformans Cryptococcus neoformanslung-draining lymph nodesIM functiongene deletion strategyablating IMM 2 macrophage polarization pathwaysInflammatory monocytesLy 6C hilungs upregulated transcriptslymphoid cellsM 2-associated transcription factor STAT 6neoformans infectionmurine survivalimmunocompromised patients
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