Gene expression differences in THP-1-derived macrophages with rough-type M. abscessus (MAB_R) infections.
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posted on 2025-01-10, 20:00 authored by Jiahua Qian, Chenghua Lu, Kai Meng, Zhihong Xu, Honghao Xue, Weijie Yang(A) Volcano plot illustrating the distribution of differentially expressed genes (DEGs) between the MAB_R and control samples. Red, blue, and gray dots represent the upregulated, downregulated, and non-significant DEGs, respectively. (B) The heatmap depicts the top 11 significantly upregulated and downregulated DEGs. (C) Boxplots depict the differences in the expression of genes between the MAB_R and control samples, with significance determined using the rank-sum test. Asterisks denote p-values; ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05.
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using bioinformatic toolstranscription factors lmnb1recent studies indicateproviding new insightsexpression network analysisweighted gene coinfluencing iron metabolismfunctional enrichment analysesexcellent predictive valuelncrnas regulate ferroptosisferroptosis may playprotein interaction networkcerna network predictedmycobacterium abscessus derived macrophages infectedmacrophages infectedhub geneenrichment assessmentdiagnostic valuecellular metabolismabscessus uninfected controlspulmonary diseasepathways relatedpathogenic mechanismsnacc2 key rnaitpkb immune responseshsd3b7 critical rolecell deathbiomarkers associatedbinding proteins
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