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Food intake, body weight, and circadian behavior of D1R KODrago mice from the cryorepository.

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posted on 08.02.2021, 18:47 by Dina R. Assali, Michael Sidikpramana, Andrew P. Villa, Jeffrey Falkenstein, Andrew D. Steele

(A) Average daily food intake for control (n = 16) and D1R KODrago-cryo (n = 8) mice in grams and (B) normalized to body weight. (C) Body weight in grams prior to CR and during 4 weeks of CR and (D) expressed as a fraction of Day 0 weight. (E) Mean ± SEM fraction of high activity behaviors on day 0 of CR. n = 19–21 for control and 9–10 for KO for all behavioral measurements. (F) Mean ± SEM fraction of high activity behaviors after 14 days of timed CR feeding. (G) Mean ± SEM fraction of high activity behaviors after 28 days of timed CR feeding. (H) Mean ± SEM total 24 hour high activity data in seconds. (I) Mean ± SEM high activity data in seconds for the 3 h preceding scheduled feeding across the experiment. (J) Normalized high activity data shown in (I) in the 3 h preceding scheduled feeding across the experiment.

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