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Fingolimod is effective in IFN-β non-responder patients with high Sema4A.

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posted on 08.03.2018, 18:41 by Toru Koda, Akiko Namba, Yuji Nakatsuji, Masaaki Niino, Yusei Miyazaki, Tomoyuki Sugimoto, Makoto Kinoshita, Kazushiro Takata, Kazuya Yamashita, Mikito Shimizu, Toshiyuki Fukazawa, Atsushi Kumanogoh, Hideki Mochizuki, Tatsusada Okuno

Relapses (A) and EDSS (B) of all the patients with high Sema4A in Osaka University Hospital who changed from IFN-β to fingolimod treatment are shown. (The orange and blue lines represent duration of treatment with fingolimod and IFN-β, respectively.) During IFN-β treatment, the patients had many relapses and disease progressed. However, fingolimod tended to be effective in reducing the relapse rate (1.36 ± 0.80 (IFN-β) to 0.27 ± 0.25 (FTY), p = 0.054; Mann-Whitney U test) and in preventing further increase in EDSS in all patients (0.45 ± 0.37 (annual EDSS change, IFN-β) to 0.0 ± 0.0 (annual EDSS change, FTY), p = 0.046; Mann-Whitney U test). The Sema4A levels (U/ml) of each patient are as follows: Pt.1; 24098, Pt.2; 3500, Pt.3; 3915, Pt.4; 6484, Pt.5; 21186, indicated within the parenthesis.

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