pmed.1003111.g002.tif (2.6 MB)

Final BN for the prediction of LNM and 5-year DSS.

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posted on 15.05.2020 by Casper Reijnen, Evangelia Gogou, Nicole C. M. Visser, Hilde Engerud, Jordache Ramjith, Louis J. M. van der Putten, Koen van de Vijver, Maria Santacana, Peter Bronsert, Johan Bulten, Marc Hirschfeld, Eva Colas, Antonio Gil-Moreno, Armando Reques, Gemma Mancebo, Camilla Krakstad, Jone Trovik, Ingfrid S. Haldorsen, Jutta Huvila, Martin Koskas, Vit Weinberger, Marketa Bednarikova, Jitka Hausnerova, Anneke A. M. van der Wurff, Xavier Matias-Guiu, Frederic Amant, Leon F. A. G. Massuger, Marc P. L. M. Snijders, Heidi V. N. Küsters-Vandevelde, Peter J. F. Lucas, Johanna M. A. Pijnenborg

(A.) Probability estimates are shown when no markers were recorded. (B.) Example of probability estimates in a case with preoperative tumor grade (grade 2), cervical cytology (atypical endometrial cells present), L1CAM expression (positive), and Ca-125 serum levels (>35 IU/ml). Probability distributions are shown in the nodes, and dependencies are indicated by the arrows connecting the nodes. If variables are not connected directly or indirectly, they are assumed to be (conditionally) independent. Often, the direction of the arrows can be given causal meaning. Red bars indicate that the specific variable is instantiated, i.e., a specific value or evidence is provided. Blue bars in the bar plots indicate the resulting probabilities of the probability distributions. Because of imputation, probability distributions vary slightly from Table 2. BN, Bayesian network; Ca-125, cancer antigen 125; DSS, disease-specific survival; LNM, lymph node metastasis; LVSI, lymphovascular space invasion; L1CAM, L1 cell adhesion molecule.