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The congenital hypothyroidism-induced hypertension in adulthood is associated with left ventricular hypertrophy due to the overexpression of oxidized CaMKII and ANP and the increase of ROS, nitrites, myeloperoxidase, catalase, GPX, GR, and the reduction of total SOD activity. Moreover, congenital hypothyroidism-induced cardiometabolic malprogramming is worsened by nutritional insult during life. Thus, congenital hypothyroidism is a risk factor to increase cardiometabolic diseases.
