Figure4_final_R1_v3.pdf

DAT-mediated psychomotor effects in mice. (A) Dose-dependent effects of the DAT inhibitor tested in the total ambulatory distance measured over 60 min from i.p. injection. (B) Linear correlation between the apparent in vivo koff and the log10 of the koff measured in vitro. Linear regression led to a straight line with the equation Y = −15.43*X − 37.7; P =0.0275, F = 8.379, r2 = 0.5827. (C–F) Comparison of the decline of action with the measured in vitro koff for cocaine and MPH (C), S- and R-αPVP (D), S- and R-MDPV (E), S- and R-Pyrovalerone (F).