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posted on 03.02.2021, 18:51 authored by Joseph A. Politch, Susan Cu-Uvin, Thomas R. Moench, Karen T. Tashima, Jai G. Marathe, Kate M. Guthrie, Howard Cabral, Tara Nyhuis, Miles Brennan, Larry Zeitlin, Hans M. L. Spiegel, Kenneth H. Mayer, Kevin J. Whaley, Deborah J. AndersonForest plots of cytokines in CVLs: (A). The ratio (relative median ± 95% confidence interval) of Visit 3 (24 hours after single film) to Baseline concentrations in Segment A, and (B). The ratio (relative median ± 95% confidence interval) of Active film Visit 4 (24 hours after seventh film) to Placebo film Visit 4 concentrations in Segment B. No significant increases in cytokine concentrations were observed following Active film insertion or in Active film vs. Placebo film group comparisons.
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MB 661 film vaginallyIC 50randomized trial Background MB 66 film24- hour time pointPlacebo film groups1 hour postdosingHSV 8-N24 hours postPK24 hours postdoseTrial registration ClinicalTrials.g...STIpost-use survey resultsMPTplaque reduction assayMB 66 filmELISACVLHIVMB 66 insertionfilm dissolution rateHSV neutralization activity7 days24 hoursAEVRC 01-N
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