Fig 5 -

The Taxonomic Distribution of TcC HVRs and Evolved VgrG C-terminal Regions (A) Sankey diagram showing the relationship between bacterial taxa (class, family and genus from left to right) and the known or predicted function of HVR protein domains (rightmost). Domains present in only one HVR are excluded for clarity. (B) Sankey diagram showing the relationship between bacterial taxa (class, family and genus from left to right) and the known or predicted functions of evolved VgrGs (rightmost). The number of sequences involved in each node is given after the name of taxon or function/domain. The red arrows on the right indicate some typical examples of HVR domains that break the taxonomical specificity. The M35_like and YwqJ-deaminase domains both present in Pseudomonas, while they also present in Salmonella and Bacillus, respectively. Although PRK15386 and PTP_DSP_cys domains are predominant in Pseudomonas and Yersinia respectively, but there are also a few exceptions (slim curves) that present in other genera.