Fig 3 -
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posted on 2023-03-22, 17:37 authored by Bercem Dutagaci, Bingbing Duan, Chenxi Qiu, Craig D. Kaplan, Michael FeigPrediction of phenotypes from TL sequence for double mutants of E1103G (A), G1097D (B), F1084I (C) and Q1078S (D).
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various stress conditionslethal substitutions tendedencoder model basedsaccharomyces cerevisiae using fitness valuesrna polymerase iimodeled phenotypes alonglethal mutations tendeddifferent phenotypes based2 ml could predictcatalysis including hypomd data allowedincorporate md datadiv >< pcharacterize tl mutations>< supmd datar pol iicontinual valuesindividual mutationsassociate phenotypesvariational autotrigger looptl residuestl ),structural detailspossibly incompletentp substratesntp substratemachine learningimprove predictionsdetermine relationshipsconformational changescause disruptionbridge helixbh ).achieves roles
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