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posted on 2023-03-22, 17:37 authored by Bercem Dutagaci, Bingbing Duan, Chenxi Qiu, Craig D. Kaplan, Michael Feig
<p>Prediction of phenotypes from TL sequence for double mutants of E1103G (A), G1097D (B), F1084I (C) and Q1078S (D).</p>

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    various stress conditionslethal substitutions tendedencoder model basedsaccharomyces cerevisiae </using fitness valuesrna polymerase iimodeled phenotypes alonglethal mutations tendeddifferent phenotypes based2 </ supml could predictcatalysis including hypomd data allowedincorporate md datadiv >< pcharacterize tl mutations>< supmd datar </pol iicontinual valuesindividual mutationsassociate phenotypesvariational autotrigger looptl residuestl ),structural detailspossibly incompletentp substratesntp substratemachine learningimprove predictionsdetermine relationshipsconformational changescause disruptionbridge helixbh ).achieves roles

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