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posted on 28.06.2021, 17:35 by Avantika Lal, Keli Liu, Robert Tibshirani, Arend Sidow, Daniele Ramazzotti

A) The 9 mutational signatures obtained by applying SparseSignatures to a dataset of 147 pancreatic tumors. We report the number and correlation of the most similar (correlation higher than 0.70) corresponding signature from COSMIC (https://cancer.sanger.ac.uk/cosmic/signatures). Source data are provided in S13 Table. B) Boxplots showing fitted values for exposure to each of the 9 signatures obtained by SparseSignatures for the 147 pancreatic tumors. Boxplots represent the fraction of mutations per tumor (on the y-axis) contributed by the given signature (on the x-axis). Source data are provided in S14 Table. C) Relapse-free survival analysis of patients belonging to the 10 clusters. D) Clustering of patients based on their exposure values. Boxplots show the fraction of mutations per tumor contributed by each signature (x- axis) to each of 10 clusters. Source data are provided in S19 Table.

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