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Far UV circular dichroism spectra of purified scFv.

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posted on 18.12.2017, 18:31 by Anna Gąciarz, Lloyd W. Ruddock

CD spectra of scFv that were found to be soluble in the absence of disulfide bonds and comparisons with the disulfide bonded counterpart. (A) scFv trastuzumab; (B) scFv natalizumab; (C) scFv trastuzumab and natalizumab and the trastuzumab framework—natalizumab CDR hybrid scFv all produced with CyDisCo; (D) trastuzumab framework—natalizumab CDR hybrid scFv. scFv frameworks which have all four cysteines mutated to alanine are indicated as CA.

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