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FBLN1 inhibits ferroptosis by reducing intracellular free ferrous iron.

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posted on 2024-12-13, 18:32 authored by Yaping Yuan, Youbo Wang, Yufeng Yan, Edward Kim, Jin Bai, Yang Zhao, Qinyun Ma, Wenchao Gu, Haihan Song
<p>(A) Fe<sup>2+</sup> kit was used to detect the changes in Fe<sup>2+</sup> concentration in MLE-12 cells after 1 μg/mL LPS+over-FBLN1 treatment. (B-E) WB was used to detect the changes in GPX4, ACSL4, and SFXN1 protein levels in MLE-12 cells after 1 μg/mL LPS+over-FBLN1 treatment. LPS, lipopolysaccharide; WB, Western blot; Fe<sup>2+</sup>, ferrous iron. *<i>p</i><0.05.</p>

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    DOI - Is supplement to <i>FBLN1</i> regulates ferroptosis in acute respiratory distress syndrome by reducing free ferrous iron by inhibiting the TGF-β/Smad pathway

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    weighted gene cosuggesting antagonistic rolespotential therapeutic strategyoxidative stress markersinduced oxidative stressdifferentially expressed genesalleviate oxidative stressacute lung injurysignificantly negatively correlatedmitigate pulmonary injuryexpression network analysisreducing cell viabilitysmad signaling pathwaydecreased cell viabilityfbln1 overexpression counteractedsmad protein levelscell viabilitysmad pathwaysignificantly downregulatedpulmonary dysfunctionexpression offersvitro </turquoise modulestudy highlightsstudy aimsros ),protein interactionogn </increased malondialdehydegse263867 datasetgria1 </ferrous ironfbln1 inhibitedfbln1 </decreased tgfcritical regulatorcol6a3 </col14a1 </12 cells

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