pone.0177319.g008.tif (2.37 MB)

FBA simulation with xylose as in silico carbon source allowing overproduction of all biomass precursors as well as NADPH, while closing the ATP balance and with both FBP and PFK reactions active.

Download (2.37 MB)
posted on 25.05.2017, 17:35 by Du Toit W. P. Schabort, Stephanus G. Kilian, James C. du Preez

Note the high growth rate, the absence of glycerol production and pyruvate dehydrogenase bypass fluxes, and the FBP/PFK substrate cycle that is responsible for the balance in ATP and ADP. The reaction names are as in Fig 1. The PFK/FBP substrate cycle serves as an alternative ATP sink in the absence of the ATP exchange flux, which represents various mechanisms of ATP utilisation.