Extended Data S-R1C - Brain heatmap pearson-correlation

Heatmap matrices of enrichment, expression and Pearson correlation between the two for each motif, in brain tissue. First five columns are gradient coloured (legend to right) according to enriched motifs of significance FDR-corrected P-value (q-value <0.05) in module gene promoters (rows as ‘_n’ module number and ‘_TF’ motifs) shown as -log(q-value) in all five extant species (columns). Next five columns are tissue-specific zero-mean log-expression expression ratios (legend to right) used as input for Arboretum (see Methods) in all five extant species (columns). Final column is Pearson correlation coefficient (PCC) of motif enrichment and expression values shown in previous columns. PCC ranges (legend to right) from 1 (positive linear correlation, blue), 0 (no linear correlation, white), and −1 (negative linear correlation, red).