Expression of CD46, CD55 and CD59 in uremic controls (uremic patients at catheter implantation) and patients on peritoneal dialysis (PD).
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PD patients were grouped according the D/P ratio creatinine and the D/D0 glucose in patients with low or low average peritoneal transport status (L/LA group) and patients with high average or high transport status (HA/H group). RNA samples from uremic controls (n = 22), patients on PD in the L/LA-group (L/LA-group, n = 13), and patients on PD in the HA/H-group (HA/H-group, n = 11). CD46, CD55 and CD59 mRNA levels were analyzed by RT-PCR. The mean fold induction of CD46, CD55 and CD59 was normalized to the housekeeping gene 18SrRNA. (A.) There were no statistically significant differences in induction of CD46 RNA expression in PD patients compared to uremic controls and between the L/LA-group compared to the HA/H. (B.) The expression of CD55 was statistically significant decreased in the HA/H-group compared to the L/LA-group and to uremic controls (p < 0.05 and p = 0.05, respectively). (C.) There were no statistically significant differences in induction of CD59 RNA expression in PD patients compared to uremic controls and between patients in the L/LA-group compared to patients in the HA/H-group were detected.