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Download fileExpanding candidate genes process.
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posted on 2022-02-22, 19:10 authored by Katherine Hartmann, Michał Seweryn, Wolfgang SadeeFlowchart portraying process of expanding candidate gene list from 75 to 245 using eQTL, sQTL, and physical position.
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wide association studieslikely causative variantsexert regulatory functionsevaluating linkage disequilibriumcoronary artery disease>., rs7528419 residing75 currently annotateduncover gwas variantstranscript specific effectstissue specific eqtlsmark functional variationlipa gene expressionidentify 3 variantsimplicated 58 lociprioritize associated genesinfluence multiple genesdiv >< p58 gwas locicad gwas resultsgwas variant rs1412444identify genessingle variantresults refinerelevant transcriptprobing tissuegenetic variationcad ).significant locirelevant genescandidate genesvast majoritysort1 rna isoformsreveal evidenceremainder helpncrnas maybeliver specificallylipa locusguyc1a1 g findings supportfactorial systeme considered togetherbiological basisalmost halfallows us
