Example of identification of regions of interest from retinal, renal, and cardiac tissues.
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posted on 2024-12-31, 18:47 authored by Eric Wang, Biao Feng, Shali Chen, Zhaoliang Su, Subrata ChakrabartiCD31+ regions corresponding to microvascular endothelial cells were identified as regions of interest for UV excision of barcoded oligonucleotides. CD31+ regions corresponding to larger vessels were excluded from UV excision.
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spatial transcriptomic approachexplore potential similaritiesinduced endothelial dysfunctionvalidated mec heterogeneityusing human retinalinfluence differential developmentdiabetic mouse modelsmicrovascular endothelial cellsfound minimal similaritiesdiv >< pdifferent target organsmajor diabetic complicationschronic diabetic complicationsendothelial cellsbasal heterogeneityneuronal cellsretinal mecsvitro vascular manifestationstranscriptomically distinctselected analytesrespond differentlyhigh glucosedifferential responsescommon originscommon origincell culturebasal state
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