Evolutionary changes in the ratio of lysine to arginine on different structural regions of the spike protein of SARS-CoV-2 lineages.

Shown are the changes in the LYS/ARG ratio in the (a) NTD, (b) RBD, and (c) S2 domain as a function of the (average) lineage divergence. Each point in the panels represents one of the 2665 different SARS-CoV-2 lineages analyzed. Thick lines show a rolling average of the LYS/ARG ratio with lineage divergence (window size contains 100 lineages).

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