Emodepside causes inhibition of motility of whole adult Brugia malayi that is concentration-, time-, and sex-dependent.

A: Representative micrograph of an untreated adult female B. malayi. The worm is characteristically coiled and was showing continuous vigorous vibrating movements. B: (female symbol) Concentration- and time-dependent emodepside inhibition of motility on adult B. malayi females and C: (male symbol) males. Motility plotted at 60 minutes for both females and males (D: female symbol: IC_{50 (female),} 801 ± 126nM (SEM)) and males (E: male symbol: IC_{50 (male),} 176 ± 33 nM (SEM)). Each treatment group was normalized to the motility at time 0. N = 12, over two biological replicate experiments. The female IC₅₀ was significantly higher than the male (p<0.001; 2-way ANOVA). The male is more sensitive to emodepside than the female.