Effect sizes of nominally significant gene-set based tests in the DeCOI<sub>EUR</sub> cohort.
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posted on 2024-12-23, 19:01 authored by Axel Schmidt, Nicolas Casadei, Fabian Brand, German Demidov, Elaheh Vojgani, Ayda Abolhassani, Rana Aldisi, Guillaume Butler-Laporte, T. Madhusankha Alawathurage, Max Augustin, Robert Bals, Carla Bellinghausen, Marc Moritz Berger, Michael Bitzer, Christian Bode, Jannik Boos, Thorsten Brenner, Oliver A. Cornely, Thomas Eggermann, Johanna Erber, Torsten Feldt, Christian Fuchsberger, Julien Gagneur, Siri Göpel, Tobias Haack, Helene Häberle, Frank Hanses, Julia Heggemann, Ute Hehr, Johannes C. Hellmuth, Christian Herr, Anke Hinney, Per Hoffmann, Thomas Illig, Björn-Erik Ole Jensen, Verena Keitel, Sarah Kim-Hellmuth, Philipp Koehler, Ingo Kurth, Anna-Lisa Lanz, Eicke Latz, Clara Lehmann, Tom Luedde, Carlo Maj, Michael Mian, Abigail Miller, Maximilian Muenchhoff, Isabell Pink, Ulrike Protzer, Hana Rohn, Jan Rybniker, Federica Scaggiante, Anna Schaffeldt, Clemens Scherer, Maximilian Schieck, Susanne V. Schmidt, Philipp Schommers, Christoph D. Spinner, Maria J. G. T. Vehreschild, Thirumalaisamy P. Velavan, Sonja Volland, Sibylle Wilfling, Christof Winter, J. Brent Richards, André Heimbach, Kerstin Becker, Stephan Ossowski, Joachim L. Schultze, Peter Nürnberg, Markus M. Nöthen, Susanne Motameny, Michael Nothnagel, Olaf Riess, Eva C. Schulte, Kerstin U. Ludwig<p>Gene-sets and the corresponding functional masks (<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012786#ppat.1012786.s012" target="_blank">S4 Table</a>) that were tested are given on the y-axis. On the x-axis, effect size estimates (betas) are shown as markers with error bars indicating the standard errors of betas. Note that phenotypes are color-coded, and the markers outlined in black indicate analyses that only included males. Nominally significant findings were only obtained in the overall analyses and male sub-stratification. None was observed in female-only or age-stratified analyses. A list of genes that were included in each gene-set can be found in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012786#ppat.1012786.s011" target="_blank">S3 Table</a>.</p>
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whole genome sequencingsuggested nominal enrichmentsestablished risk geneentire frequency spectrumentire allelic spectrume ., europeans3p21 reaching genome220 mainly vaccineenabling joint analysesbased joint analyseslargest population subgroupsuggestive causal variantsdiv >< pcontrol analysesmale subgroupwide significancevariation acrosstlr7 </though researchsystematic assessmentstill lackingsignificantly youngerrare variantsoverall analysiskey locushighly variabledifferent typesdependent mannerburden testing2 infections2 infection
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