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Effect of systemically delivered IFN-β at the onset of arthritis in mice with collagen-induced arthritis

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posted on 31.12.2011, 04:37 authored by Judith van Holten, Kris Reedquist, Pascale Sattonet-Roche, Tom JM Smeets, Christine Plater-Zyberk, Margriet J Vervoordeldonk, Paul P Tak

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Taken from "Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis"

Arthritis Research & Therapy 2004;6(3):R239-R249.

Published online 23 Mar 2004


Copyright © 2004 van Holten et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Clinical score (mean ± ) was assessed on a scale of 0 to 3.5 (as described in Materials and methods), and hind paw swelling (mean ± ) of the first arthritic paw was monitored during the course of disease using calipers. On day 7 after the start of the treatment, differences between all treatment groups and the control group were statistically significant (= 0.005) (Kruskal–Wallis test). Arrows mark the first day of treatment. *Statistically significant difference. , standard error of the mean.


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