pntd.0006806.g005.tif (126.64 kB)
Effect of pepstatin A in interaction assay of P. brasiliensis and macrophage cells.
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posted on 2018-09-27, 17:35 authored by Daniele Gonçalves Castilho, Alison Felipe Alencar Chaves, Marina Valente Navarro, Palloma Mendes Conceição, Karen Spadari Ferreira, Luiz Severino da Silva, Patricia Xander, Wagner Luiz BatistaP. brasiliensis yeast cells were treated with pepstatin A on concentrations of 15 and 30 μM during 1 h before interaction assay. Pepstatin A increase phagocytosis (A) and enhance antifungal activity of macrophages reducing colony forming units (B). Data were analyzed using Student’s t-test. Error bars correspond to the standard deviation of measurements performed in triplicate, and * indicates a significant difference (*p<0.05).
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loadPbSAP expressionhost invasion processlung parenchymapepstatinvirulence regulatoraspartyl protease inhibitorvirulence factorsrPbSap-immunized micePCM modelParacoccidioides brasiliensis infection ParacoccidioidomycosisVirulence factorsParacoccidioides genusAspartyl proteasesLatin Americaphagocytic profileParacoccidioides brasiliensisSecreted aspartyl proteinase
