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Download fileEffect of dexamethasone (DEX) treatment on the expression of ubiquitin-proteasome-related factors involved with protein catabolism.
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posted on 2016-05-26, 20:48 authored by Ruxia Wang, Hongchao Jiao, Jingpeng Zhao, Xiaojuan Wang, Hai LinThe total FoxO1 protein (A), phospho-FoxO1/3a (Thr 24/32) (B), FoxO1 and FoxO3 mRNA levels (C), MuRF1 protein (D), MuRF1 mRNA (E), atrogin-1 protein (F), and atrogin-1 mRNA (G) in C2C12 cells treated with DEX (100 μM) for 36 h. The values are presented as the means ± SEM (n = 6). a,b Means with different letters differ significantly (P < 0.05).
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glucocorticoid-induced muscle protein turnoverGlucocorticoids Enhance Muscle ProteolysismTORDEX treatmentmuscle protein synthesisMuRFProtein synthesis ratesThrprotein synthesis rateglucocorticoid-induced muscle protein catabolismphosphorylation levelsmyostatinTGF -β superfamilyp 70Sglucocorticoid-induced muscle atrophy
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