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Effect of deleting relatively inactive neurons is partially recovered with plasticity.

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posted on 23.09.2020, 17:34 authored by David Gabrieli, Samantha N. Schumm, Nicholas F. Vigilante, Brandon Parvesse, David F. Meaney

(A) Representative raster plots before injury, at 50% low firing rate (LFR) excitatory neuron injury, and after network restructuring with STDP. (B) LFR damage produced a rapid decline to baseline firing after injury that significantly recovered with STDP. (C,D) This restoration was primarily due to a recovery of network oscillation frequency and magnitude. (E) Changes in oscillation width occurred relative to baseline, primarily following damage exceeding the threshold of full firing rate restoration.