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Effect of chemotherapy on mechanical sensitivity in C56BL/6J male mice.

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posted on 26.01.2017 by Preet G. S. Makker, Samuel S. Duffy, Justin G. Lees, Chamini J. Perera, Ryan S. Tonkin, Oleg Butovsky, Susanna B. Park, David Goldstein, Gila Moalem-Taylor

Time course of mechanical paw withdrawal threshold (PWT; in grams) of male C56BL/6J mice treated with paclitaxel (PTX), oxaliplatin (OXA) or saline (control). Measurements were taken from baseline before chemotherapy until day 27, with chemotherapy injections administered at days 0, 2, 4 and 6. Compared to baseline thresholds, significant decrease in PWT was seen on days 8, 13, and 16 in the PTX-treated group, and on days 8, 13, 16 and 27 in the OXA-treated group. **(P<0.01); ***(P<0.001); ****(P<0.0001) indicate significant difference between baseline and post-chemotherapy time points in the PTX group. ++(P<0.01); +++(P<0.001); ++++(P<0.0001) indicate significant difference between baseline and post-chemotherapy time points in the OXA group. PTX (n = 16), OXA (n = 16), Saline (n = 15). RM two-way ANOVA followed by Bonferroni’s multiple comparisons test. Data are expressed as mean±SEM.

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