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Effect of P4 individual fractions on aldosterone-induced human mineralocorticoid receptor (hMR) transcriptional activity.

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posted on 29.10.2014, 03:00 by Beatriz Martín-Fernández, Natalia de las Heras, María Valero-Muñoz, Sandra Ballesteros, Yi-Zhou Yao, Peter G. Stanton, Peter J. Fuller, Vicente Lahera

CV-1 cells transfected with hMR expression and MMTV-LUC reporter plasmids were treated with vehicle (V) or aldosterone 1 nM (A1 nM) in presence of spironolactone 100 nM (S100 nM) or fractions (F) 31 to 40 (1 µM), blank (B) and blank+aldosterone1 nM (B+A1 nM). Each data point represents the mean ± SEM derived from 3 independent experiments. *p<0.01 vs V; p<0.05 vs. A1 nM.