Effect of FGF23 administration on mineral and hormonal levels.

Urinary and plasma concentrations of Pi (A and B) and Ca²⁺ (C and D) as well as plasma levels of PTH (E), endogenous FGF23 (F), 1,25(OH)₂D (G) and recombinant human FGF23 (H) were measured in samples from mice injected with recombinant human FGF23 (rhFGF23) once a day for two consecutive days (black bars) and the respective vehicle treated controls (white bars). Graphs show mean ± SD (n = 5-6/group) and data was analyzed by unpaired student’s t-test with significant p values indicated as: * p ≤ 0.05 and ** p ≤ 0.01.