Effect of EGCG on hippocampal synaptic plasticity markers.
(a) EGCG treatment normalized Bdnf mRNA levels in CD animals. A two-way ANOVA indicated a significant interaction between genotypes and treatment (F1,38 = 5.512, p = 0.0242), with a significant effect of genotype (F1,38 = 6.599, p = 0.0143) and treatment (F1,38 = 30.47, p<0.0001). (b) EGCG treatment did not normalize the high Pik3r1 mRNA levels observed in the hippocampus of CD mice. A two-way ANOVA indicated a significant effect of treatment (F1,24 = 7.406, p = 0.0119), since EGCG treatment upregulated Pik3r1 mRNA levels in WT animals. n = 6–13 per group. p values are shown with asterisks (genotype) or hashes (treatment) indicating values that are significantly different (two-way ANOVA with Bonferroni post hoc test). *,#p<0.05; **,##p<0.01; ***,###p<0.001. White, WT; Black, CD. Plain, water; Striped, EGCG. Data are presented as the mean ± SEM.