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Effect of [D-Lys3]-GHRP-6 on the antihyperalgesic effect of RKT against paclitaxel-induced mechanical hyperalgesia in mice.

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posted on 09.02.2017, 19:03 by Junzo Kamei, Shunsuke Hayashi, Akane Sakai, Yuki Nakanishi, Misa Kai, Megumi Ikegami, Hiroko Ikeda

(A) Time course of the effect of [D-Lys3]-GHRP-6 (10 mg/kg, i.p.) on the antihyperalgesic effect of RKT (1 g/kg, p.o.) on the mean mechanical threshold in paclitaxel-treated mice. (B) Effect of [D-Lys3]-GHRP-6 (10 mg/kg, i.p.) on the antihyperalgesic effect of RKT (1 g/kg, p.o.) on the mean mechanical threshold in paclitaxel-treated mice on day 3. Paclitaxel (5 mg/kg, i.p.) and RKT (1 g/kg, p.o.) were injected once a day for 3 days. [D-Lys3]-GHRP-6 (10mg/kg, i.p.) was injected on day 2, 15 min before the administration of RKT. RKT was administered 1 hour before each nociceptive test. The nociceptive threshold was determined by the von Frey filament test. Each point represents the mean ± S.E.M of 6–8 mice. ***P < 0.001 vs saline-DW-paclitaxel group, ###P < 0.001 vs saline-RKT-paclitaxel group.

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