pone.0207844.g005.tif (1.73 MB)

Effect of AngII-infusion and CSD treatment on caveolin and calpain isoforms in the heart and kidney.

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posted on 21.12.2018, 18:37 by Panneerselvam Chinnakkannu, Charles Reese, John Antony Gaspar, Saraswathi Panneerselvam, Dorea Pleasant-Jenkins, Rupak Mukherjee, Catalin Baicu, Elena Tourkina, Stanley Hoffman, Dhandapani Kuppuswamy

Mice were infused with AngII or saline for 2 wk and received daily i.p. injections of CSD or vehicle. Extracts were prepared as described in the previous figure legends. (A) RIPA extracts of LV and kidney tissues were used in Western blotting experiments with antibodies against caveolin-1 (cav-1), caveolin-3 (cav-3) and β-actin (loading control). (B) RIPA extracts of LV tissue and kidney tissues were used in Western blotting experiments with antibodies against μ-calpain (μ-Calp), m-calpain (m-Calp), and β-actin (loading control). No statistically significant effects of AngII or CSD were observed.

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