pone.0208633.g004.tif (1.37 MB)

Effect of 17β-estradiol treatment and exercise training on cardiac mitochondria–dependent apoptotic pathway.

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posted on 20.12.2018, 18:33 by Yi-Yuan Lin, Jwo-Sheng Chen, Xu-Bo Wu, Woei-Cherng Shyu, Rungchai Chaunchaiyakul, Xian-Li Zhao, Chia-Hua Kuo, Yu-Jung Cheng, Ai-Lun Yang, Shin-Da Lee

(A) The representative protein products of t-Bid, Bad, Bax, Cytochrome c, activated caspase 9 and activated caspase 3 were extracted from the left ventricles of excised hearts of the sham-operated (Sham), bilateral ovariectomized (OVX), OVX treated with 17β-estradiol (OVX-E2) and OVX rats treated with 17β-estradiol and exercise (OVX-E2-EX) were measured by Western Blotting analysis. (B) The bars represent the relative protein quantification of t-Bid, Bad, Bax, and Cytochrome c, activated caspase 9 and activated caspase 3 on the basis of α-tubulin and indicate mean values ± SD (n = 8 in each group). **P<0.01, indicate significant differences from the Sham group. ##P<0.01, indicate significant differences from the OVX group. P<0.05, †† P<0.01, indicate significant differences between the OVX-E2 and OVX-E2-EX group.

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