pone.0210305.g001.tif (1.58 MB)

ENTPD5 is an ER-resident UDPase important for proper glycoprotein folding.

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posted on 2019-06-26, 17:29 authored by Matthew A. Durst, Kiira Ratia, Arnon Lavie

Schematic diagram highlighting the role ENTPD5 plays in the glycoprotein refolding cycle in the ER. For proper glycoprotein folding to occur, UDP-glucose is brought into the ER by an antiporter that uses UMP as the counter molecule. ENTPD5 activity produces UMP, leading to increased levels of UDP-glucose entering the ER for glycoprotein refolding. ENTPD5 expression is upregulated through two independent pathways: PI3K-AKT axis signaling and mutant p53 interactions.