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Dynamics of HIV-1 NL4-3 infection through cell-to-cell and cell-free infection without or with IFN-α.

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posted on 2022-04-25, 17:29 authored by Ryuichi Kumata, Shoya Iwanami, Katrina B. Mar, Yusuke Kakizoe, Naoko Misawa, Shinji Nakaoka, Yoshio Koyanagi, Alan S. Perelson, John W. Schoggins, Shingo Iwami, Kei Sato

Jurkat cells were infected with HIV-1 strain NL4-3 at MOI 0.1 in the static and shaking culture under treated with IFN-α or untreated. Time-course experimental data and the fitting of Model 1 (see Methods). The time-course of experimental data for the numbers of uninfected cells (top) and infected cells (middle), and the amount of viral p24 antigen in the culture supernatant (bottom) in the static culture (left) and shaking culture (right) are shown. Gray and orange curves respectively indicate the results in the absence or presence of IFN-α treatment, respectively. The dots with error bars are the averages and SEMs of three independent experiments. The shadow regions correspond to 95% posterior predictive intervals, and the curves give the best-fit solution Model 1 to the experimental dataset.