pone.0281363.g005.tif (161.46 kB)
Dose response curves showing the effects of OT, carbetocin, FBOT, and HPOT on strength of contraction of the mouse uterus.
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posted on 2023-02-09, 18:46 authored by Stanislav M. Cherepanov, Teruko Yuhi, Takashi Iizuka, Takashi Hosono, Masanori Ono, Hiroshi Fujiwara, Shigeru Yokoyama, Satoshi Shuto, Haruhiro HigashidaMouse myometrial contractility were recorded as shown in Fig 4 from seven virgin mice. Contraction strength was calculated from the area under the curve (AUC). n = 3−5 for each dot; 100% indicates AUC of spontaneous contraction.
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virgin female micerelated deaths worldwidepotentiate postpartum hemorrhagen -( 3major risk factorinsufficient uterine toneex vivo n -( pdiv >< pvirgin mouse uteruspotency rank judgedth superior uterine contractionrefractory uterine atonyoxytocin partial agonist efficacytwo oxytocin analogshuman ot receptorshpot showed additivityvitro uterine contractionstrongest agonisthuman uterushuman samplesuteri isolatedsmall amountsresults suggestedperformed betterparturient processesot treatmentot doseot antagonistmain causelabor arresthpot treatmenthpot )],highly uterotonichighly associatedelicit rapidcompound 2cesarean deliverycalculated emaxcalculated ecblood loss100 %).090 ).
