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Download fileDolutegravir concentration (ng/ml), mean (+/- SD) fetal (red line) and maternal (blue line) concentrations for all placentas in recirculating closed-circuit ex vivo human perfused cotyledon model, n = 5 experiments.
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posted on 2019-08-13, 17:28 authored by Laurent Mandelbrot, Pierre-François Ceccaldi, Dominique Duro, Minh Lê, Lucile Pencolé, Gilles PeytavinDolutegravir concentration (ng/ml), mean (+/- SD) fetal (red line) and maternal (blue line) concentrations for all placentas in recirculating closed-circuit ex vivo human perfused cotyledon model, n = 5 experiments.
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tissue accumulationtransplacental pharmacokineticsrecirculating experimentsex-vivo dually perfused cotyledon modelcotyledon accumulation index3 hPlacental transferantipyrine transferrecirculating perfusionSDplacental tissuefetal-to-maternal ratioHIV integrase inhibitor dolutegravirstudy design Maternal-to-fetal transferclearance indexcotyledon perfusion model ObjectiveDTG concentrations
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