pone.0234236.g003.tif (937.03 kB)
Download fileDistributions of log10 Month 13 MN (Panels A, C, E, G) and PRNT50 (Panels B, D, F, H) titers in CYD14 participants (all ages = 2 to 14 years old), stratified by treatment group and case status (serotype-matched vs serotype-mismatched cases).
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posted on 2020-06-15, 20:04 authored by Lindsay N. Carpp, Youyi Fong, Matthew Bonaparte, Zoe Moodie, Michal Juraska, Ying Huang, Brenda Price, Yingying Zhuang, Jason Shao, Lingyi Zheng, Laurent Chambonneau, Robert Small, Saranya Sridhar, Carlos A. DiazGranados, Peter B. GilbertThe gray horizontal shaded band denotes the middle third of nAb responses (log10 MN titer = 1.23 − 2.03; log10 PRNT50 titer 1.76 − 2.42). A “matched-serotype case” is one where the VCD-causing virus was of the same serotype as the virus used in the nAb assay; a “nonmatched-serotype case” is one where the VCD-causing virus was of a different serotype than the virus used in the nAb assay.
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Month 13 PRNT 50 titernext-generation high-throughput microneutralizationphase 3 trialsMonth 13 MN titervaccine efficacyMonth 13 MN titersCYD-TDV tetravalent dengue vaccineDENVMonth 13 MNCYD 15 Phase 3 trialsMonth 13 titerimmuno-bridging applicationsMicroneutralization assay titer correlates analysisPRNT 50 informationPRNT 50 titersMonth 13VCDVEPRNT 50
