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Distribution of reported classifications of variants in different inherited CDs causing non-ischemic SCD.

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posted on 19.08.2020, 17:40 by Wei-Chih Huang, Hsin-Tzu Huang, Po-Yuan Chen, Wei-Chi Wang, Tai-Ming Ko, Sirjana Shrestha, Chi-Dung Yang, Chun-San Tai, Men-Yee Chiew, Yu-Pao Chou, Yu-Feng Hu, Hsien-Da Huang

Variants of uncertain significance accounted for the majority in these inherited CDs. The percentage of pathogenic/likely-pathogenic variants was high in LQTS and HCM, accounting for 51.9% and 45.5%, respectively. HCM: Hypertrophic cardiomyopathy; ARVC: Arrhythmogenic right ventricular cardiomyopathy; LQTS: Long QT syndrome; BrS: Brugada syndrome; CPVT: Catecholaminergic polymorphic ventricular tachycardia.

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