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Distribution of log-likelihood ratio scores for T-cell repertoires.

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posted on 2023-02-24, 19:07 authored by María Ruiz Ortega, Natanael Spisak, Thierry Mora, Aleksandra M. Walczak
<p>Distribution of log-likelihood ratio scores for 1000 T-cell repertoires belonging to the test cohort of 700 COVID-19 patients and 300 healthy individuals. The distribution of scores for each group completely overlaps, leading to a classifier with a very poor accuracy.</p> <p>(TIFF)</p>

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    PLOS Genetics

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    random generation processmodel underestimates sharingknown viral specificitycommon functional selectionaccurate diagnostic toolusing probabilistic modelingdriven convergent selectioncell receptor repertoirespublic receptors sharedpublic receptorscell membraneswide vaccinessuccess reliesshow manysequence featuresprotein receptorspreviously reportednetwork organizationindividuals infectedidentify coviddeveloping populationassociated receptors

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