Diagnostic capability of DCP for detecting early HCC with a solitary tumor smaller than 3cm.

(A and B) The concentrations of serum DCP in HCC according to tumor size (<3cm, ≥3 and ≤5cm, >5 and ≤10cm, or >10cm). (C and D) ROC curves of DCP, AFP, or their combination in HCC with a solitary small tumor (≤3cm) versus all controls (HCs and DC). (E and F) ROC curves of DCP, AFP, or their combination in HCC with a solitary small tumor (≤3cm) versus disease controls (G and H). The positive rates of serum DCP and AFP in HCC according to tumor size (<3cm, ≥3 and ≤5cm, >5 and ≤10cm, or >10cm). DCP, des-gamma-carboxy prothrombin; AFP, alpha-fetoprotein; HCC, hepatocellular carcinoma; HC, healthy control; DC, disease control; ROC, receiver operating characteristics; AUC, area under the curve; 95% CI, 95% confidence interval.