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Determining the role of STAT-3 signaling in pom-induced increases in ICAM-1 and B7-2.

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posted on 07.01.2021, 19:26 by Prabha Shrestha, David A. Davis, Hannah K. Jaeger, Alexandra Stream, Ashley I. Aisabor, Robert Yarchoan

(A) Surface expression levels of ICAM-1 and B7-2 in BCBL-1 cells 48 hours after treatment with DMSO ctrl or STAT3 inhibitor S3I-201 (10 and 100μM). (B) BCBL-1 cells were pretreated with S3I-201 for approximately 1 hour and then treated with 1μM Pom for another 48 hours. Histograms show ICAM-1 and B7-2 levels in the presence of 1μM Pom alone or in combination with S3I-201. Cells were stained with PerCP/Cy5.5-conjugated antibodies and analyzed using flow cytometry.