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Detail of F-type ATP synthase subunits missing in T. gondii and other apicomplexan parasites.

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posted on 13.07.2018, 17:22 by Rahul Salunke, Tobias Mourier, Manidipa Banerjee, Arnab Pain, Dhanasekaran Shanmugam

(A) Schematic representation of core subunit composition of F-type ATP synthase. The different subunits are color coded and annotated. Middle, the complete set of subunits of the core enzyme; left and right, subunits identified and not identified by in silico methods in apicomplexan genome. (B) Table showing the presence/absence of orthologs of yeast and bovine F-type ATP synthase in Apicomplexa and other alveolate species. +/−, presence/absence of ortholog; blue, diverged (no clear orthologs) functional equivalent; light blue, experimentally identified species-specific novel subunits (numeric values indicate the total number of such novel subunits). Species names: Pfal, P. falciparum; Pviv, Plasmodium vivax; Tpar, Theileria parva; Bbov, Babesia bovis; Tgon, T. gondii; Ncan, Neospora caninum; Cmur, Cryptosporidium muris; Cpar, Cryptosporidium parvum; Chom, Cryptosporidium hominis; Cvel, Chromera velia; Pmar, Perkinsus marinus; Tthe, T. thermophila; Scer, Saccharomyces cerevisiae; Btau, Bos taurus; Atha, Arabidopsis thaliana; Crei, Chlamydomonas reinhardtii; Tbru, T. brucei. IF1, inhibitory factor 1; OSCP, oligomycin sensitivity–conferring protein.

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