Despite CAR DNA vector integration, D1D2 CAR is not detected on the cell surface.
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posted on 2024-08-12, 17:23 authored by Giorgio Zenere, Chengxiang Wu, Cecily C. Midkiff, Nathan M. Johnson, Christopher P. Grice, William C. Wimley, Amitinder Kaur, Stephen E. BraunA. Histogram representing qPCR results and CAR DNA copy number in transduced HEK293 T cells. B. Representative flow plots showing surface detection of CAR by anti myc-tag antibody transfected HEK293T cells. C. Representative flow plots showing surface detection of CAR by anti-CD4 antibody in transfected HEK293T cells. D. Vector map representing the bicistronic GFP constructs.
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sup >+structural analysis studiesestablish fundamental guidelinesdemonstrated clinical potentialchimeric antigen receptorstrong surface expressionevaluating important elementsdiv >< pconstruct chronic hiv infectioncar surface expressionextracellular car expressioncar expressionidentified elementshiv carhiv envnovel carcytotoxic carcar motifscar )-partially recoverednovel antifqkas motifflow cytometryextracellular domainexpress extracellularlydetectable intracellularlyconfocal microscopycell killing
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