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Cytolytic activity of lymphocytes stimulated with putrescine and all-retinoic acid (ATRA) treated dendritic cells (DCs)

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posted on 31.12.2011, 00:01 by Alban Gervais, Jean Levêque, Françoise Bouet-Toussaint, Florence Burtin, Thierry Lesimple, Laurent Sulpice, Jean-Jacques Patard, Noelle Genetet, Véronique Catros-Quemener

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Taken from "Dendritic cells are defective in breast cancer patients: a potential role for polyamine in this immunodeficiency"

Breast Cancer Research 2005;7(3):R326-R335.

Published online 25 Feb 2005

PMCID:PMC1143555.

Copyright © 2005 Gervais et al.; licensee BioMed Central Ltd

Immature DCs were from healthy donors and were treated with putrescine (Put) with or without ATRA before DCs pulsed with treated tumour cells (DC-Tu) preparation. Autologous lymphocytes were stimulated with DC-Tu, and data are expressed as cytolytic activity (with standard error) against M74 target cell line. Presented data are from seven different donors. Controls are nonstimulated lymphocytes (NSL). Decrease in M74 lysis was repeatedly observed for each of the donors in DC + Put compared with DC, and increased in DC + Put + ATRA as compared with DC + Put. *< 0.05 versus NSL.

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